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3uwk

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[[Image:3uwk.jpg|left|200px]]
 
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==Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation==
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The line below this paragraph, containing "STRUCTURE_3uwk", creates the "Structure Box" on the page.
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<StructureSection load='3uwk' size='340' side='right'caption='[[3uwk]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3uwk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UWK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0DF:1-METHYL-6-PHENYL-1,3-DIHYDRO-2H-IMIDAZO[4,5-B]PYRIDIN-2-ONE'>0DF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3uwk| PDB=3uwk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uwk OCA], [https://pdbe.org/3uwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uwk RCSB], [https://www.ebi.ac.uk/pdbsum/3uwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uwk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_PSEAE KTHY_PSEAE] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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===Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation===
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==See Also==
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_22243413}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22243413 is the PubMed ID number.
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Chang J]]
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{{ABSTRACT_PUBMED_22243413}}
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[[Category: Choi JY]]
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[[Category: Desbonnet CR]]
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==About this Structure==
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[[Category: Dillman K]]
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[[3uwk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UWK OCA].
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[[Category: Miller AA]]
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[[Category: Miller JR]]
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==Reference==
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[[Category: Plummer MS]]
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<ref group="xtra">PMID:022243413</ref><references group="xtra"/>
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[[Category: Roush WR]]
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[[Category: Pseudomonas aeruginosa]]
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[[Category: Soutter HH]]
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[[Category: DTMP kinase]]
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[[Category: Starr J]]
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[[Category: Chang, J.]]
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[[Category: Choi, J Y.]]
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[[Category: Desbonnet, C R.]]
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[[Category: Dillman, K.]]
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[[Category: Miller, A A.]]
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[[Category: Miller, J R.]]
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[[Category: Plummer, M S.]]
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[[Category: Roush, W R.]]
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[[Category: Soutter, H H.]]
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[[Category: Starr, J.]]
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[[Category: Kinase]]
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[[Category: Thymidine triphosphate]]
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[[Category: Thymidylate kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation

PDB ID 3uwk

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