3v3k
From Proteopedia
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| - | [[Image:3v3k.jpg|left|200px]] | ||
| - | + | ==Human caspase 9 in complex with bacterial effector protein== | |
| + | <StructureSection load='3v3k' size='340' side='right'caption='[[3v3k]], [[Resolution|resolution]] 3.49Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3v3k]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V3K FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.494Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v3k OCA], [https://pdbe.org/3v3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v3k RCSB], [https://www.ebi.ac.uk/pdbsum/3v3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v3k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASP9_HUMAN CASP9_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).<ref>PMID:15657060</ref> Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.<ref>PMID:15657060</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Caspase 3D structures|Caspase 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[Category: Escherichia coli | + | [[Category: Escherichia coli O157:H7]] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Maskos K]] |
| - | [[Category: | + | [[Category: Moertl M]] |
| - | [[Category: | + | [[Category: Steuber H]] |
| - | + | ||
Current revision
Human caspase 9 in complex with bacterial effector protein
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