3v5q
From Proteopedia
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==Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models== | ==Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models== | ||
| - | <StructureSection load='3v5q' size='340' side='right' caption='[[3v5q]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='3v5q' size='340' side='right'caption='[[3v5q]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3v5q]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3v5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V5Q FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0F4:1-(3-{[(3Z)-2-OXO-3-(1H-PYRROL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOL-6-YL]AMINO}PHENYL)-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA'>0F4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2001Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0F4:1-(3-{[(3Z)-2-OXO-3-(1H-PYRROL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOL-6-YL]AMINO}PHENYL)-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA'>0F4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v5q OCA], [https://pdbe.org/3v5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v5q RCSB], [https://www.ebi.ac.uk/pdbsum/3v5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v5q ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [https://www.uniprot.org/uniprot/NTRK3_HUMAN NTRK3_HUMAN] Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. | ||
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| + | ==See Also== | ||
| + | *[[TrkB tyrosine kinase receptor|TrkB tyrosine kinase receptor]] | ||
| + | *[[Tyrosine kinase receptor 3D structures|Tyrosine kinase receptor 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Kreusch | + | [[Category: Kreusch A]] |
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Current revision
Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models
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