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3wrp

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{{Seed}}
 
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[[Image:3wrp.png|left|200px]]
 
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==FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR==
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The line below this paragraph, containing "STRUCTURE_3wrp", creates the "Structure Box" on the page.
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<StructureSection load='3wrp' size='340' side='right'caption='[[3wrp]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3wrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WRP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wrp OCA], [https://pdbe.org/3wrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wrp RCSB], [https://www.ebi.ac.uk/pdbsum/3wrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wrp ProSAT]</span></td></tr>
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{{STRUCTURE_3wrp| PDB=3wrp | SCENE= }}
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</table>
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== Function ==
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===FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR===
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[https://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_3375234}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 3375234 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/3wrp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_3375234}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3wrp ConSurf].
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3WRP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WRP OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Flexibility of the DNA-binding domains of trp repressor., Lawson CL, Zhang RG, Schevitz RW, Otwinowski Z, Joachimiak A, Sigler PB, Proteins. 1988;3(1):18-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3375234 3375234]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Sigler, P B.]]
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[[Category: Sigler PB]]
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[[Category: Zhang, R G.]]
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[[Category: Zhang R-G]]
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[[Category: Dna binding regulatory protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:12:36 2008''
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Current revision

FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR

PDB ID 3wrp

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