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405d

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(New page: 200px<br /><applet load="405d" size="350" color="white" frame="true" align="right" spinBox="true" caption="405d, resolution 2.50&Aring;" /> '''STRUCTURE OF A 16-ME...)
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[[Image:405d.gif|left|200px]]<br /><applet load="405d" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="405d, resolution 2.50&Aring;" />
 
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'''STRUCTURE OF A 16-MER RNA DUPLEX R(GCAGACUUAAAUCUGC)2 WITH WOBBLE LIKE A.C MISMATCHES'''<br />
 
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==Overview==
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==STRUCTURE OF A 16-MER RNA DUPLEX R(GCAGACUUAAAUCUGC)2 WITH WOBBLE LIKE A.C MISMATCHES==
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The crystal structure of a 16-mer, the longest known RNA duplex, has been, determined at 2.5 A resolution. The hexadecamer r(GCAGACUUAAAUCUGC), contains isolated C.A/A.C mismatches with two hydrogen bonds. The two, hydrogen bonds in the mismatches suggests that N1 of A is protonated even, though the crystallization was done at neutral pH. Therefore, the C.A, mismatch is a C.A+ wobble similar to the G.U wobble. The two C.A+ pairs, are isolated by four Watson-Crick pairs and flanked by five Watson-Crick, base-pairs on either sides. Kinks/bends of 20 degrees are observed at the, wobble sites. The Watson-Crick base-pair A5.U26 on the 5'-side of the, first C6.A27(+) wobble has a twist angle of 27 degrees compared to the, 3'-side U7.A28 pair of 36 degrees. The twist angles are reversed (37, degrees and 26 degrees) in the second A11(+).C22 wobble because of the, approximate dyad in the molecule, the flanking base-pair sequences are A.U, pairs. The wobbles expand the major groove to 7.1 A/7.3 A. The duplexes, form helical columns and are tightly packed around the 31-screw axis. The, minor grooves of adjacent columns in juxtaposition interact through the, O2' atoms and the anionic phosphate oxygen atoms.Copyright 1998 Academic, Press.
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<StructureSection load='405d' size='340' side='right'caption='[[405d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[405d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=405D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=405D FirstGlance]. <br>
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405D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=405D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=405d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=405d OCA], [https://pdbe.org/405d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=405d RCSB], [https://www.ebi.ac.uk/pdbsum/405d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=405d ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structure of a 16-mer RNA duplex r(GCAGACUUAAAUCUGC)2 with wobble C.A+ mismatches., Pan B, Mitra SN, Sundaralingam M, J Mol Biol. 1998 Nov 13;283(5):977-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9799637 9799637]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Mitra, S.N.]]
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[[Category: Large Structures]]
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[[Category: Pan, M.Sundaralingam B.]]
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[[Category: Mitra SN]]
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[[Category: a-rna double helix]]
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[[Category: Pan B]]
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[[Category: Sundaralingam M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:42:14 2008''
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Current revision

STRUCTURE OF A 16-MER RNA DUPLEX R(GCAGACUUAAAUCUGC)2 WITH WOBBLE LIKE A.C MISMATCHES

PDB ID 405d

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