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4d8l

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[[Image:4d8l.png|left|200px]]
 
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{{STRUCTURE_4d8l| PDB=4d8l | SCENE= }}
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==Crystal structure of the 2-pyrone-4,6-dicarboxylic acid hydrolase from sphingomonas paucimobilis==
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<StructureSection load='4d8l' size='340' side='right'caption='[[4d8l]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal structure of the 2-pyrone-4,6-dicarboxylic acid hydrolase from sphingomonas paucimobilis===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4d8l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2qah 2qah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D8L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D8L FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22475079}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d8l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d8l OCA], [https://pdbe.org/4d8l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d8l RCSB], [https://www.ebi.ac.uk/pdbsum/4d8l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d8l ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[4d8l]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Sphingomonas_paucimobilis Sphingomonas paucimobilis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2qah 2qah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D8L OCA].
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== Function ==
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[[Category: 2-pyrone-4,6-dicarboxylate lactonase]]
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[https://www.uniprot.org/uniprot/LIGI_SPHSK LIGI_SPHSK] Contributes to the degradation of lignin at the level of the protocatechuate 4,5-cleavage pathway (PubMed:9864312). Catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate (PDC) to (4E)-oxalomesaconate (OMA) (PubMed:29658701, PubMed:22475079). The keto form of OMA can tautomerize into the enol form, 4-carboxy-2-hydroxymuconate (CHM), under certain pH conditions (PubMed:22475079). Also catalyzes the reverse reaction (PubMed:22475079, PubMed:9864312). Is essential for the growth of Sphingobium sp. SYK-6 on vanillate but is not responsible for the growth of this strain on syringate (PubMed:9864312).<ref>PMID:22475079</ref> <ref>PMID:29658701</ref> <ref>PMID:9864312</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Sphingomonas paucimobilis]]
[[Category: Sphingomonas paucimobilis]]
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[[Category: Almo, S C.]]
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[[Category: Almo SC]]
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[[Category: Bonanno, J.]]
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[[Category: Bonanno J]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Malashkevich, V N.]]
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[[Category: Malashkevich VN]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M.]]
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[[Category: Toro R]]
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[[Category: Toro, R.]]
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[[Category: Hydrolase]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: New york structural genomix research consortium]]
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[[Category: Nysgxrc]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of the 2-pyrone-4,6-dicarboxylic acid hydrolase from sphingomonas paucimobilis

PDB ID 4d8l

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