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4de5

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[[Image:4de5.jpg|left|200px]]
 
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{{STRUCTURE_4de5| PDB=4de5 | SCENE= }}
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==Pantothenate synthetase in complex with fragment 6==
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<StructureSection load='4de5' size='340' side='right'caption='[[4de5]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4de5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DE5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DE5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0JD:(2S)-2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC+ACID'>0JD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4de5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4de5 OCA], [https://pdbe.org/4de5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4de5 RCSB], [https://www.ebi.ac.uk/pdbsum/4de5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4de5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref>
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===Pantothenate synthetase in complex with fragment 6===
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==See Also==
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*[[Pantothenate synthetase|Pantothenate synthetase]]
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== References ==
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==About this Structure==
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<references/>
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[[4de5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DE5 OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Pantoate--beta-alanine ligase]]
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[[Category: Silvestre HL]]
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[[Category: Silvestre, H L.]]
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[[Category: Alpha beta/adenine nucleotide alpha hydrolase-like]]
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[[Category: Fragment-based drug discovery]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Pantoate and b-ala binding]]
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[[Category: Pantoate-beta-alanine ligase]]
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[[Category: Protein in complex with fragment]]
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Current revision

Pantothenate synthetase in complex with fragment 6

PDB ID 4de5

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