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4e1z
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4e1z is ON HOLD Authors: Argiriadi, M.A., Talanian, R.V., Borhani, D.W. Description: Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibi...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor== | |
| + | <StructureSection load='4e1z' size='340' side='right'caption='[[4e1z]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4e1z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E1Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MX:N-[5-(4-{[(3-CHLOROPHENYL)SULFONYL]AMINO}PHENYL)-1H-INDAZOL-3-YL]FURAN-2-CARBOXAMIDE'>0MX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e1z OCA], [https://pdbe.org/4e1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e1z RCSB], [https://www.ebi.ac.uk/pdbsum/4e1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e1z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TYK2_MOUSE TYK2_MOUSE] Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities. | ||
| - | + | ==See Also== | |
| - | + | *[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Argiriadi MA]] | ||
| + | [[Category: Borhani DW]] | ||
| + | [[Category: Talanian RV]] | ||
Current revision
Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
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