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4e1z

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[[Image:4e1z.jpg|left|200px]]
 
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{{STRUCTURE_4e1z| PDB=4e1z | SCENE= }}
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==Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor==
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<StructureSection load='4e1z' size='340' side='right'caption='[[4e1z]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4e1z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E1Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MX:N-[5-(4-{[(3-CHLOROPHENYL)SULFONYL]AMINO}PHENYL)-1H-INDAZOL-3-YL]FURAN-2-CARBOXAMIDE'>0MX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e1z OCA], [https://pdbe.org/4e1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e1z RCSB], [https://www.ebi.ac.uk/pdbsum/4e1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e1z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYK2_MOUSE TYK2_MOUSE] Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities.
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===Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor===
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==See Also==
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*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]]
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{{ABSTRACT_PUBMED_22995073}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4e1z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1Z OCA].
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Argiriadi MA]]
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[[Category: Argiriadi, M A.]]
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[[Category: Borhani DW]]
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[[Category: Borhani, D W.]]
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[[Category: Talanian RV]]
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[[Category: Talanian, R V.]]
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[[Category: Kinase]]
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[[Category: Kinase catalytic domain]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor

PDB ID 4e1z

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