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4ehr

From Proteopedia

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[[Image:4ehr.png|left|200px]]
 
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==Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide==
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The line below this paragraph, containing "STRUCTURE_4ehr", creates the "Structure Box" on the page.
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<StructureSection load='4ehr' size='340' side='right'caption='[[4ehr]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4ehr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EHR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Q5:4-[5-BUTYL-3-(HYDROXYMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL]-3-(3,4-DIHYDROISOQUINOLIN-2(1H)-YLCARBONYL)-N-{[2-(TRIMETHYLSILYL)ETHYL]SULFONYL}BENZAMIDE'>0Q5</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene></td></tr>
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{{STRUCTURE_4ehr| PDB=4ehr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ehr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ehr OCA], [https://pdbe.org/4ehr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ehr RCSB], [https://www.ebi.ac.uk/pdbsum/4ehr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ehr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
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===Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide===
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22608393}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22608393 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22608393}}
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==About this Structure==
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[[4ehr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EHR OCA].
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==Reference==
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<ref group="xtra">PMID:022608393</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banfi, P.]]
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[[Category: Large Structures]]
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[[Category: Borzilleri, R M.]]
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[[Category: Banfi P]]
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[[Category: Cai, Z.]]
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[[Category: Borzilleri RM]]
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[[Category: Galvani, A.]]
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[[Category: Cai Z]]
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[[Category: Lippy, J.]]
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[[Category: Galvani A]]
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[[Category: Lombardo, L J.]]
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[[Category: Lippy J]]
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[[Category: Menichincheri, M.]]
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[[Category: Lombardo LJ]]
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[[Category: Modugno, M.]]
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[[Category: Menichincheri M]]
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[[Category: Naglich, J.]]
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[[Category: Modugno M]]
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[[Category: Penhallow, B.]]
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[[Category: Naglich J]]
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[[Category: Perez, H L.]]
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[[Category: Penhallow B]]
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[[Category: Sack, J.]]
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[[Category: Perez HL]]
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[[Category: Schmidt, R J.]]
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[[Category: Sack J]]
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[[Category: Schroeder, G M.]]
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[[Category: Schmidt RJ]]
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[[Category: Tebben, A.]]
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[[Category: Schroeder GM]]
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[[Category: Wei, D.]]
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[[Category: Tebben A]]
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[[Category: Yan, C.]]
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[[Category: Wei D]]
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[[Category: Zhang, L.]]
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[[Category: Yan C]]
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[[Category: Apoptosis]]
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[[Category: Zhang L]]
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[[Category: Bcl-2 family]]
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[[Category: Programmed cell death]]
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Current revision

Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide

PDB ID 4ehr

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