This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4er5
From Proteopedia
(Difference between revisions)
m (Protected "4er5" [edit=sysop:move=sysop]) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777== | |
| + | <StructureSection load='4er5' size='340' side='right'caption='[[4er5]], [[Resolution|resolution]] 2.57Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4er5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er5 OCA], [https://pdbe.org/4er5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er5 RCSB], [https://www.ebi.ac.uk/pdbsum/4er5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | ||
| - | + | ==See Also== | |
| - | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Bradner JE]] | ||
| + | [[Category: Brown PJ]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Federation A]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Marineau J]] | ||
| + | [[Category: Nguyen KT]] | ||
| + | [[Category: Qi J]] | ||
| + | [[Category: Schapira M]] | ||
| + | [[Category: Scopton A]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Vedadi M]] | ||
| + | [[Category: Wernimont AK]] | ||
| + | [[Category: Yu W]] | ||
Current revision
Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bradner JE | Brown PJ | Edwards AM | Federation A | Li Y | Marineau J | Nguyen KT | Qi J | Schapira M | Scopton A | Tempel W | Vedadi M | Wernimont AK | Yu W
