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4er5
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==Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777== | ==Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777== | ||
| - | <StructureSection load='4er5' size='340' side='right' caption='[[4er5]], [[Resolution|resolution]] 2.57Å' scene=''> | + | <StructureSection load='4er5' size='340' side='right'caption='[[4er5]], [[Resolution|resolution]] 2.57Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4er5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4er5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QK:7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)(PROPAN-2-YL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>0QK</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er5 OCA], [https://pdbe.org/4er5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er5 RCSB], [https://www.ebi.ac.uk/pdbsum/4er5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er5 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. |
==See Also== | ==See Also== | ||
| - | *[[Histone methyltransferase|Histone methyltransferase]] | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Bradner | + | [[Category: Bradner JE]] |
| - | [[Category: Brown | + | [[Category: Brown PJ]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Federation | + | [[Category: Federation A]] |
| - | [[Category: Li | + | [[Category: Li Y]] |
| - | [[Category: Marineau | + | [[Category: Marineau J]] |
| - | [[Category: Nguyen | + | [[Category: Nguyen KT]] |
| - | [[Category: Qi | + | [[Category: Qi J]] |
| - | + | [[Category: Schapira M]] | |
| - | [[Category: Schapira | + | [[Category: Scopton A]] |
| - | [[Category: Scopton | + | [[Category: Tempel W]] |
| - | [[Category: Tempel | + | [[Category: Vedadi M]] |
| - | [[Category: Vedadi | + | [[Category: Wernimont AK]] |
| - | [[Category: Wernimont | + | [[Category: Yu W]] |
| - | [[Category: Yu | + | |
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Current revision
Crystal structure of human DOT1L in complex with 2 molecules of EPZ004777
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Bradner JE | Brown PJ | Edwards AM | Federation A | Li Y | Marineau J | Nguyen KT | Qi J | Schapira M | Scopton A | Tempel W | Vedadi M | Wernimont AK | Yu W
