This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4ewi
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4ewi is ON HOLD Authors: Eibl, C., Hessenberger, M., Puehringer, S., Page, R., Diederichs, K., Peti, W. Description: Crystal structure of the NLRP4...) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the NLRP4 Pyrin domain== | |
| + | <StructureSection load='4ewi' size='340' side='right'caption='[[4ewi]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ewi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EWI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ewi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ewi OCA], [https://pdbe.org/4ewi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ewi RCSB], [https://www.ebi.ac.uk/pdbsum/4ewi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ewi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NALP4_HUMAN NALP4_HUMAN] May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.<ref>PMID:12093792</ref> <ref>PMID:22388039</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Pyrin domain|Pyrin domain]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Diederichs K]] | ||
| + | [[Category: Eibl C]] | ||
| + | [[Category: Hessenberger M]] | ||
| + | [[Category: Page R]] | ||
| + | [[Category: Peti W]] | ||
| + | [[Category: Puehringer S]] | ||
Current revision
Crystal structure of the NLRP4 Pyrin domain
| |||||||||||
