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4fpa
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate== | |
| + | <StructureSection load='4fpa' size='340' side='right'caption='[[4fpa]], [[Resolution|resolution]] 2.48Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fpa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FPA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BG6:BETA-D-GLUCOSE-6-PHOSPHATE'>BG6</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fpa OCA], [https://pdbe.org/4fpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fpa RCSB], [https://www.ebi.ac.uk/pdbsum/4fpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fpa ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN] Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:[https://omim.org/entry/235700 235700]. HK deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HXK1_HUMAN HXK1_HUMAN] | ||
| - | + | ==See Also== | |
| - | + | *[[Hexokinase 3D structures|Hexokinase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Honzatko RB]] | ||
| + | [[Category: Shen L]] | ||
Current revision
Crystal Structure of recombinant human Hexokinase type I mutant D413N Glucose 6-Phosphate
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