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4fw6
From Proteopedia
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| - | {{STRUCTURE_4fw6| PDB=4fw6 | SCENE= }} | ||
| - | ===Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]-4-(PHENYLETHYNYL)BENZAMIDE inhibitor=== | ||
| - | == | + | ==Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]-4-(PHENYLETHYNYL)BENZAMIDE inhibitor== |
| - | [[http://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE | + | <StructureSection load='4fw6' size='340' side='right'caption='[[4fw6]], [[Resolution|resolution]] 1.83Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4fw6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FW6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=L59:N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]-4-(PHENYLETHYNYL)BENZAMIDE'>L59</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fw6 OCA], [https://pdbe.org/4fw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fw6 RCSB], [https://www.ebi.ac.uk/pdbsum/4fw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fw6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LPXC_PSEAE LPXC_PSEAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[UDP-3-O-acyl-N-acetylglucosamine deacetylase|UDP-3-O-acyl-N-acetylglucosamine deacetylase]] |
| - | [[Category: Pseudomonas aeruginosa | + | __TOC__ |
| - | [[Category: Kang | + | </StructureSection> |
| - | [[Category: Stuckey | + | [[Category: Large Structures]] |
| - | + | [[Category: Pseudomonas aeruginosa PAO1]] | |
| - | + | [[Category: Kang YN]] | |
| + | [[Category: Stuckey JA]] | ||
Current revision
Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]-4-(PHENYLETHYNYL)BENZAMIDE inhibitor
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