This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4g09
From Proteopedia
(Difference between revisions)
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==The crystal structure of the C366S mutant of HDH from Brucella suis in complex with a substituted benzyl ketone== | |
| - | + | <StructureSection load='4g09' size='340' side='right'caption='[[4g09]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4g09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brucella_suis_1330 Brucella suis 1330]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G09 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0VD:(3S)-3-AMINO-1-[4-(BENZYLOXY)PHENYL]-4-(1H-IMIDAZOL-4-YL)BUTAN-2-ONE'>0VD</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g09 OCA], [https://pdbe.org/4g09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g09 RCSB], [https://www.ebi.ac.uk/pdbsum/4g09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g09 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HISX_BRUSU HISX_BRUSU] Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brucella suis 1330]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: D'Ambrosio K]] | ||
| + | [[Category: De Simone G]] | ||
Current revision
The crystal structure of the C366S mutant of HDH from Brucella suis in complex with a substituted benzyl ketone
| |||||||||||
