This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4g20
From Proteopedia
(Difference between revisions)
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:4g20.jpg|left|200px]] | ||
| - | + | ==Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor== | |
| - | + | <StructureSection load='4g20' size='340' side='right'caption='[[4g20]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4g20]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G20 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=484:3-(5-{2-[3,4-BIS(HYDROXYMETHYL)PHENYL]ETHYL}-2-METHYL-2-PROPYLBIPHENYL-4-YL)PENTAN-3-OL'>484</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g20 OCA], [https://pdbe.org/4g20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g20 RCSB], [https://www.ebi.ac.uk/pdbsum/4g20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g20 ProSAT]</span></td></tr> |
| - | [[4g20]] is a 2 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Danio rerio]] | [[Category: Danio rerio]] | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Ciesielski | + | [[Category: Large Structures]] |
| - | [[Category: Moras | + | [[Category: Ciesielski F]] |
| - | [[Category: Rochel | + | [[Category: Moras D]] |
| - | [[Category: Sato | + | [[Category: Rochel N]] |
| - | + | [[Category: Sato Y]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Structural basis for the accommodation of bis- and tris-aromatic derivatives in Vitamin D Nuclear Receptor
| |||||||||||
