4g28
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4g28 is ON HOLD Authors: Zhang, M., Pascal, J.M., Zhang, J.-f. Description: Calcium-calmodulin complexed with the calmodulin binding domain from a ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and EBIO-1== | |
| + | <StructureSection load='4g28' size='340' side='right'caption='[[4g28]], [[Resolution|resolution]] 1.63Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4g28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G28 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0W8:1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE'>0W8</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g28 OCA], [https://pdbe.org/4g28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g28 RCSB], [https://www.ebi.ac.uk/pdbsum/4g28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g28 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KCNN2_RAT KCNN2_RAT] Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. | ||
| - | + | ==See Also== | |
| - | + | *[[Calmodulin 3D structures|Calmodulin 3D structures]] | |
| - | + | *[[Potassium channel 3D structures|Potassium channel 3D structures]] | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Pascal JM]] | ||
| + | [[Category: Zhang J-F]] | ||
| + | [[Category: Zhang M]] | ||
Current revision
Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and EBIO-1
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