4g2l
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4g2l is ON HOLD Authors: Liu,S Description: human pde9 in complex with selective compound) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Human PDE9 in complex with selective compound== | |
| + | <StructureSection load='4g2l' size='340' side='right'caption='[[4g2l]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4g2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WL:1-CYCLOPENTYL-6-{(1R)-1-[3-(PYRIMIDIN-2-YL)AZETIDIN-1-YL]ETHYL}-1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE'>0WL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2l OCA], [https://pdbe.org/4g2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2l RCSB], [https://www.ebi.ac.uk/pdbsum/4g2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Liu S]] | ||
Current revision
Human PDE9 in complex with selective compound
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