4g2l

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{{STRUCTURE_4g2l| PDB=4g2l | SCENE= }}
 
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===Human PDE9 in complex with selective compound===
 
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{{ABSTRACT_PUBMED_23025719}}
 
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==Function==
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==Human PDE9 in complex with selective compound==
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[[http://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN]] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
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<StructureSection load='4g2l' size='340' side='right'caption='[[4g2l]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g2l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G2L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WL:1-CYCLOPENTYL-6-{(1R)-1-[3-(PYRIMIDIN-2-YL)AZETIDIN-1-YL]ETHYL}-1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE'>0WL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2l OCA], [https://pdbe.org/4g2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g2l RCSB], [https://www.ebi.ac.uk/pdbsum/4g2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref>
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==About this Structure==
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==See Also==
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[[4g2l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2L OCA].
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023025719</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Liu, S.]]
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[[Category: Large Structures]]
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[[Category: Cgmp->gmp]]
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[[Category: Liu S]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inhibitor complex]]
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[[Category: Phosphodiesterase]]
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Current revision

Human PDE9 in complex with selective compound

PDB ID 4g2l

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