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4g3u

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(New page: '''Unreleased structure''' The entry 4g3u is ON HOLD Authors: Li, H., Jogl, G. Description: Mycobacterium smegmatis DprE1 -monoclinic crystal form)
Current revision (11:25, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4g3u is ON HOLD
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==Mycobacterium smegmatis DprE1 - monoclinic crystal form==
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<StructureSection load='4g3u' size='340' side='right'caption='[[4g3u]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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Authors: Li, H., Jogl, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4g3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis Mycolicibacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G3U FirstGlance]. <br>
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Description: Mycobacterium smegmatis DprE1 -monoclinic crystal form
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.689&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g3u OCA], [https://pdbe.org/4g3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g3u RCSB], [https://www.ebi.ac.uk/pdbsum/4g3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g3u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPRE1_MYCS2 DPRE1_MYCS2] Component of the DprE1-DprE2 complex that catalyzes the 2-step epimerization of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-arabinose (DPA), a key precursor that serves as the arabinose donor required for the synthesis of cell-wall arabinans (PubMed:22188377). DprE1 catalyzes the first step of epimerization, namely FAD-dependent oxidation of the C2' hydroxyl of DPR to yield the keto intermediate decaprenyl-phospho-2'-keto-D-arabinose (DPX) (PubMed:22188377). The intermediate DPX is then transferred to DprE2 subunit of the epimerase complex, most probably through a 'substrate channel' at the interface of DprE1-DprE2 complex (By similarity). Can also use farnesyl-phosphoryl-beta-D-ribofuranose (FPR) as substrate in vitro (PubMed:22188377, PubMed:22956199). Appears to be essential for the growth of M.smegmatis (PubMed:21346818).[UniProtKB:P9WJF1]<ref>PMID:21346818</ref> <ref>PMID:22188377</ref> <ref>PMID:22956199</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mycolicibacterium smegmatis]]
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[[Category: Jogl G]]
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[[Category: Li H]]

Current revision

Mycobacterium smegmatis DprE1 - monoclinic crystal form

PDB ID 4g3u

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