4g55

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==Clathrin terminal domain complexed with pitstop 2==
==Clathrin terminal domain complexed with pitstop 2==
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<StructureSection load='4g55' size='340' side='right' caption='[[4g55]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
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<StructureSection load='4g55' size='340' side='right'caption='[[4g55]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4g55]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xzh 2xzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G55 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4g55]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xzh 2xzh]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G55 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=VH2:N-[5-[(4-BROMOPHENYL)METHYL]-4-HYDROXY-1,3-THIAZOL-2-YL]NAPHTHALENE-1-SULFONAMIDE'>VH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xzg|2xzg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=VH2:N-[5-[(4-BROMOPHENYL)METHYL]-4-HYDROXY-1,3-THIAZOL-2-YL]NAPHTHALENE-1-SULFONAMIDE'>VH2</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLH17, CLTC, CLTCL2, KIAA0034 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g55 OCA], [https://pdbe.org/4g55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g55 RCSB], [https://www.ebi.ac.uk/pdbsum/4g55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g55 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g55 OCA], [http://pdbe.org/4g55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g55 RCSB], [http://www.ebi.ac.uk/pdbsum/4g55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g55 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CLH1_HUMAN CLH1_HUMAN]] Translocation renal cell carcinoma;Inflammatory myofibroblastic tumor.
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[https://www.uniprot.org/uniprot/CLH1_HUMAN CLH1_HUMAN] Translocation renal cell carcinoma;Inflammatory myofibroblastic tumor.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLH1_HUMAN CLH1_HUMAN]] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
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[https://www.uniprot.org/uniprot/CLH1_HUMAN CLH1_HUMAN] Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Clathrin-mediated endocytosis (CME) regulates many cell physiological processes such as the internalization of growth factors and receptors, entry of pathogens, and synaptic transmission. Within the endocytic network, clathrin functions as a central organizing platform for coated pit assembly and dissociation via its terminal domain (TD). We report the design and synthesis of two compounds named pitstops that selectively block endocytic ligand association with the clathrin TD as confirmed by X-ray crystallography. Pitstop-induced inhibition of clathrin TD function acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle recycling. Endocytosis inhibition is caused by a dramatic increase in the lifetimes of clathrin coat components, including FCHo, clathrin, and dynamin, suggesting that the clathrin TD regulates coated pit dynamics. Pitstops provide new tools to address clathrin function in cell physiology with potential applications as inhibitors of virus and pathogen entry and as modulators of cell signaling.
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Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.,von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, Macgregor KA, Tomlin N, Pechstein A, Chau N, Chircop M, Sakoff J, von Kries JP, Saenger W, Krausslich HG, Shupliakov O, Robinson PJ, McCluskey A, Haucke V Cell. 2011 Aug 5;146(3):471-84. PMID:21816279<ref>PMID:21816279</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4g55" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Clathrin|Clathrin]]
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*[[Clathrin 3D structures|Clathrin 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Bulut, H]]
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[[Category: Large Structures]]
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[[Category: Haucke, V]]
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[[Category: Bulut H]]
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[[Category: Kleist, L Von]]
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[[Category: Haucke V]]
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[[Category: Saenger, W]]
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[[Category: Saenger W]]
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[[Category: Beta-propeller]]
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[[Category: Von Kleist L]]
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[[Category: Endocytosis]]
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Current revision

Clathrin terminal domain complexed with pitstop 2

PDB ID 4g55

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