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4gal

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(New page: 200px<br /> <applet load="4gal" size="450" color="white" frame="true" align="right" spinBox="true" caption="4gal, resolution 1.95&Aring;" /> '''CRYSTAL STRUCTURE O...)
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[[Image:4gal.gif|left|200px]]<br />
 
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<applet load="4gal" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="4gal, resolution 1.95&Aring;" />
 
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'''CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE==
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Knowledge about carbohydrate recognition domains of galectins, formerly, known as S-type animal lectins, is important in understanding their, role(s) in cell-cell interactions. Here we report the crystal structure of, human galectin-7 (hGal-7), in free form and in the presence of galactose, galactosamine, lactose, and N-acetyl-lactosamine at high resolution. This, is the first structure of a galectin determined in both free and, carbohydrate-bound forms. The structure shows a fold similar to that of, the prototype galectins -1 and -2, but has greater similarity to a related, galectin molecule, Gal-10. Even though the carbohydrate-binding residues, are conserved, there are significant changes in this pocket due to, shortening of a loop structure. The monomeric hGal-7 molecule exists as a, dimer in the crystals, but adopts a packing arrangement considerably, different from that of Gal-1 and Gal-2, which has implications for, carbohydrate recognition.
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<StructureSection load='4gal' size='340' side='right'caption='[[4gal]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gal]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GAL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gal FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gal OCA], [https://pdbe.org/4gal PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gal RCSB], [https://www.ebi.ac.uk/pdbsum/4gal PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gal ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LEG7_HUMAN LEG7_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/4gal_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4gal ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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4GAL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4GAL OCA].
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*[[Galectin 3D structures|Galectin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structural basis for the recognition of carbohydrates by human galectin-7., Leonidas DD, Vatzaki EH, Vorum H, Celis JE, Madsen P, Acharya KR, Biochemistry. 1998 Oct 6;37(40):13930-40. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9760227 9760227]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Acharya, K.R.]]
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[[Category: Acharya KR]]
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[[Category: Leonidas, D.D.]]
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[[Category: Leonidas DD]]
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[[Category: carbohydrate binding]]
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[[Category: galaptin]]
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[[Category: galectin]]
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[[Category: lectin]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:50:37 2007''
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Current revision

CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE

PDB ID 4gal

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