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4gd4

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==Crystal Structure of JMJD2A Complexed with Inhibitor==
==Crystal Structure of JMJD2A Complexed with Inhibitor==
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<StructureSection load='4gd4' size='340' side='right' caption='[[4gd4]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
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<StructureSection load='4gd4' size='340' side='right'caption='[[4gd4]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4gd4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GD4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GD4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4gd4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GD4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GD4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0WS:2-(1H-PYRAZOL-3-YL)PYRIDINE-4-CARBOXYLIC+ACID'>0WS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0WS:2-(1H-PYRAZOL-3-YL)PYRIDINE-4-CARBOXYLIC+ACID'>0WS</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/4gd4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gd4 OCA], [https://pdbe.org/4gd4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gd4 RCSB], [https://www.ebi.ac.uk/pdbsum/4gd4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gd4 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
==See Also==
==See Also==
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*[[Jumonji domain-containing protein 2A|Jumonji domain-containing protein 2A]]
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*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A]]
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[[Category: Bountra C]]
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[[Category: King, O N.F]]
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[[Category: Edwards A]]
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[[Category: Krojer, T]]
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[[Category: King ONF]]
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[[Category: McDonough, M A]]
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[[Category: Krojer T]]
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[[Category: Structural genomic]]
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[[Category: McDonough MA]]
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[[Category: Schofield, C J]]
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[[Category: Schofield CJ]]
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[[Category: 2-oxoglutarate]]
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[[Category: Alpha-ketoglutarate]]
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[[Category: Chromatin regulator]]
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[[Category: Demethylation]]
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[[Category: Dioxygenase]]
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[[Category: Iron]]
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[[Category: Jmjc domain]]
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[[Category: Nucleus]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Sgc]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of JMJD2A Complexed with Inhibitor

PDB ID 4gd4

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