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4ggd
From Proteopedia
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| - | [[Image:4ggd.jpg|left|200px]] | ||
| - | + | ==Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.== | |
| + | <StructureSection load='4ggd' size='340' side='right'caption='[[4ggd]], [[Resolution|resolution]] 2.44Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ggd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GGD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GGD FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.435Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ggd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ggd OCA], [https://pdbe.org/4ggd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ggd RCSB], [https://www.ebi.ac.uk/pdbsum/4ggd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ggd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CDC20_HUMAN CDC20_HUMAN] Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.<ref>PMID:9811605</ref> <ref>PMID:9734353</ref> <ref>PMID:9637688</ref> | ||
| - | == | + | ==See Also== |
| - | + | *[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Luo | + | [[Category: Luo X]] |
| - | [[Category: Tian | + | [[Category: Tian W]] |
| - | [[Category: Tomchick | + | [[Category: Tomchick DR]] |
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Current revision
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
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