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4gq1

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Nup37 of S. pombe

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Retrieved from "http://52.214.119.220/wiki/index.php/4gq1"

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 ==Nup37 of S. pombe==
-<StructureSection load='4gq1' size='340' side='right' caption='[[4gq1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+<StructureSection load='4gq1' size='340' side='right'caption='[[4gq1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4gq1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GQ1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4gq1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GQ1 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gq2|4gq2]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Nup37, SPAC4F10.18 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gq1 OCA], [https://pdbe.org/4gq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gq1 RCSB], [https://www.ebi.ac.uk/pdbsum/4gq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gq1 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gq1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gq1 RCSB], [http://www.ebi.ac.uk/pdbsum/4gq1 PDBsum]</span></td></tr>
 </table>
-<div style="background-color:#fffaf0;">
+== Function ==
-== Publication Abstract from PubMed ==
+[https://www.uniprot.org/uniprot/YEKI_SCHPO YEKI_SCHPO]
-The coatomer module of the nuclear pore complex borders the cylinder-like nuclear pore-membrane domain of the nuclear envelope. In evolution, a single coatomer module increases in size from hetero-heptamer (Saccharomyces cerevisiae) to hetero-octamer (Schizosaccharomyces pombe) to hetero-nonamer (Metazoa). Notably, the heptamer-octamer transition proceeds through the acquisition of the nucleoporin Nup37. How Nup37 contacts the heptamer remained unknown. Using recombinant nucleoporins, we show that Sp-Nup37 specifically binds the Sp-Nup120 member of the hetero-heptamer but does not bind an Sc-Nup120 homolog. To elucidate the Nup37-Nup120 interaction at the atomic level, we carried out crystallographic analyses of Sp-Nup37 alone and in a complex with an N-terminal, approximately 110-kDa fragment of Sp-Nup120 comprising residues 1-950. Corroborating structural predictions, we determined that Nup37 folds into a seven-bladed beta-propeller. Several disordered surface regions of the Nup37 beta-propeller assume structure when bound to Sp-Nup120. The N-terminal domain of Sp-Nup120(1-950) also folds into a seven-bladed propeller with a markedly protruding 6D-7A insert and is followed by a contorted helical domain. Conspicuously, this 6D-7A insert contains an extension of 50 residues which also is highly conserved in Metazoa but is absent in Sc-Nup120. Strikingly, numerous contacts with the Nup37 beta-propeller are located on this extension of the 6D-7A insert. Another contact region is situated toward the end of the helical region of Sp-Nup120(1-950). Our findings provide information about the evolution and the assembly of the coatomer module of the nuclear pore complex.
-Structural evolution of the membrane-coating module of the nuclear pore complex.,Liu X, Mitchell JM, Wozniak RW, Blobel G, Fan J Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16498-503. doi:, 10.1073/pnas.1214557109. Epub 2012 Sep 26. PMID:23019579<ref>PMID:23019579</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Schizosaccharomyces pombe]]
-[[Category: Blobel, G]]
+[[Category: Blobel G]]
-[[Category: Fan, J]]
+[[Category: Fan J]]
-[[Category: Liu, X]]
+[[Category: Liu X]]
-[[Category: Mitchell, J]]
+[[Category: Mitchell J]]
-[[Category: Wozniak, R]]
+[[Category: Wozniak R]]
-[[Category: Propeller]]
-[[Category: Transport protein]]

4gq1

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Nup37 of S. pombe

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