4gsy

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[[Image:4gsy.png|left|200px]]
 
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{{STRUCTURE_4gsy| PDB=4gsy | SCENE= }}
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==Crystal structure of thymidylate kinase from Staphylococcus aureus bound to inhibitor.==
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<StructureSection load='4gsy' size='340' side='right'caption='[[4gsy]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4gsy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_N315 Staphylococcus aureus subsp. aureus N315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GSY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0Y5:4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]METHYL}-2-[3-(TRIFLUOROMETHYL)PHENOXY]BENZOIC+ACID'>0Y5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gsy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gsy OCA], [https://pdbe.org/4gsy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gsy RCSB], [https://www.ebi.ac.uk/pdbsum/4gsy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gsy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KTHY_STAAR KTHY_STAAR] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity).
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===Crystal structure of thymidylate kinase from Staphylococcus aureus bound to inhibitor.===
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==See Also==
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*[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]]
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{{ABSTRACT_PUBMED_23043329}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4gsy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_n315 Staphylococcus aureus subsp. aureus n315]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSY OCA].
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[[Category: Staphylococcus aureus subsp. aureus N315]]
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[[Category: Staphylococcus aureus subsp. aureus n315]]
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[[Category: Larsen NA]]
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[[Category: DTMP kinase]]
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[[Category: Olivier NB]]
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[[Category: Larsen, N A.]]
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[[Category: Olivier, N B.]]
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[[Category: Atp binding]]
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[[Category: Kinase activity]]
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[[Category: Nucleotide binding]]
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[[Category: Thymidylate kinase activity]]
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[[Category: Transferase]]
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[[Category: Transferase activity]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of thymidylate kinase from Staphylococcus aureus bound to inhibitor.

PDB ID 4gsy

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