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4gwv
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| - | {{STRUCTURE_4gwv| PDB=4gwv | SCENE= }} | ||
| - | ===Structure of racemic Pin1 WW domain cocrystallized with tri-ammonium citrate=== | ||
| - | == | + | ==Structure of racemic Pin1 WW domain cocrystallized with tri-ammonium citrate== |
| - | [[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN | + | <StructureSection load='4gwv' size='340' side='right'caption='[[4gwv]], [[Resolution|resolution]] 3.05Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4gwv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4GWV FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4gwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gwv OCA], [https://pdbe.org/4gwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4gwv RCSB], [https://www.ebi.ac.uk/pdbsum/4gwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4gwv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Forest KT]] |
| - | [[Category: | + | [[Category: Gellman SH]] |
| - | [[Category: | + | [[Category: Mortenson DE]] |
| - | + | [[Category: Yun HG]] | |
| - | + | ||
Current revision
Structure of racemic Pin1 WW domain cocrystallized with tri-ammonium citrate
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