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4hd0
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4hd0 is ON HOLD Authors: Limbo, O., Moiani, D., Kertokalio, A., Wyman, C., Tainer, J.A., Russell, P. Description: Mre11 ATLD17/18 mutation retains ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair== | |
| - | + | <StructureSection load='4hd0' size='340' side='right'caption='[[4hd0]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4hd0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HD0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HD0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hd0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hd0 OCA], [https://pdbe.org/4hd0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hd0 RCSB], [https://www.ebi.ac.uk/pdbsum/4hd0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hd0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MRE11_PYRFU MRE11_PYRFU] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pyrococcus furiosus DSM 3638]] | ||
| + | [[Category: Kertokalio A]] | ||
| + | [[Category: Limbo O]] | ||
| + | [[Category: Moiani D]] | ||
| + | [[Category: Russell P]] | ||
| + | [[Category: Tainer JA]] | ||
| + | [[Category: Wyman C]] | ||
Current revision
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair
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