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4hor
From Proteopedia
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| - | [[Image:4hor.jpg|left|200px]] | ||
| - | + | ==Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligocytidine== | |
| - | + | <StructureSection load='4hor' size='340' side='right'caption='[[4hor]], [[Resolution|resolution]] 1.86Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4hor]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HOR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.861Å</td></tr> | |
| - | == | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CTP:CYTIDINE-5-TRIPHOSPHATE'>CTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[4hor]] is a 2 chain structure with sequence from [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hor OCA], [https://pdbe.org/4hor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hor RCSB], [https://www.ebi.ac.uk/pdbsum/4hor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hor ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IFIT5_HUMAN IFIT5_HUMAN] Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.<ref>PMID:23317505</ref> <ref>PMID:23334420</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Abbas | + | [[Category: Large Structures]] |
| - | [[Category: Gorna | + | [[Category: Abbas YM]] |
| - | [[Category: Nagar | + | [[Category: Gorna MW]] |
| - | [[Category: Pichlmair | + | [[Category: Nagar B]] |
| - | [[Category: Superti-Furga | + | [[Category: Pichlmair A]] |
| - | + | [[Category: Superti-Furga G]] | |
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Current revision
Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligocytidine
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