4hos

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[[Image:4hos.png|left|200px]]
 
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{{STRUCTURE_4hos| PDB=4hos | SCENE= }}
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==Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine==
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<StructureSection load='4hos' size='340' side='right'caption='[[4hos]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4hos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HOS FirstGlance]. <br>
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{{ABSTRACT_PUBMED_23334420}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hos OCA], [https://pdbe.org/4hos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hos RCSB], [https://www.ebi.ac.uk/pdbsum/4hos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hos ProSAT]</span></td></tr>
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[[4hos]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOS OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IFIT5_HUMAN IFIT5_HUMAN] Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.<ref>PMID:23317505</ref> <ref>PMID:23334420</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Abbas, Y M.]]
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[[Category: Large Structures]]
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[[Category: Gorna, M W.]]
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[[Category: Abbas YM]]
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[[Category: Nagar, B.]]
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[[Category: Gorna MW]]
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[[Category: Pichlmair, A.]]
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[[Category: Nagar B]]
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[[Category: Superti-Furga, G.]]
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[[Category: Pichlmair A]]
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[[Category: Antiviral]]
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[[Category: Superti-Furga G]]
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[[Category: Rna]]
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[[Category: Rna binding]]
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[[Category: Rna binding protein-rna complex]]
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[[Category: Tpr]]
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Current revision

Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine

PDB ID 4hos

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