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4hrf
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Atomic structure of DUSP26== | |
| + | <StructureSection load='4hrf' size='340' side='right'caption='[[4hrf]], [[Resolution|resolution]] 1.68Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4hrf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HRF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hrf OCA], [https://pdbe.org/4hrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hrf RCSB], [https://www.ebi.ac.uk/pdbsum/4hrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hrf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DUS26_HUMAN DUS26_HUMAN] Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).<ref>PMID:15796912</ref> <ref>PMID:16924234</ref> <ref>PMID:17001450</ref> <ref>PMID:16581800</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | |
| - | + | *[[MAP kinase phosphatase|MAP kinase phosphatase]] | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bhardwaj A]] | ||
| + | [[Category: Cingolani G]] | ||
| + | [[Category: Lokareddy RK]] | ||
Current revision
Atomic structure of DUSP26
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