This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4i1b

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:48, 1 March 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:4i1b.png|left|200px]]
 
-
<!--
+
==FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE==
-
The line below this paragraph, containing "STRUCTURE_4i1b", creates the "Structure Box" on the page.
+
<StructureSection load='4i1b' size='340' side='right'caption='[[4i1b]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[4i1b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I1B FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1b OCA], [https://pdbe.org/4i1b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i1b RCSB], [https://www.ebi.ac.uk/pdbsum/4i1b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1b ProSAT]</span></td></tr>
-
{{STRUCTURE_4i1b| PDB=4i1b | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/IL1B_HUMAN IL1B_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.<ref>PMID:3920526</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/4i1b_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4i1b ConSurf].
 +
<div style="clear:both"></div>
-
===FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE===
+
==See Also==
-
 
+
*[[Interleukin 3D structures|Interleukin 3D structures]]
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_1553379}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 1553379 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_1553379}}
+
-
 
+
-
==About this Structure==
+
-
4I1B is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1B OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:1553379</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Gilliland, G L.]]
+
[[Category: Large Structures]]
-
[[Category: Hirai, Y.]]
+
[[Category: Gilliland GL]]
-
[[Category: Masui, Y.]]
+
[[Category: Hirai Y]]
-
[[Category: Poulos, T L.]]
+
[[Category: Masui Y]]
-
[[Category: Raag, R.]]
+
[[Category: Poulos TL]]
-
[[Category: Svensson, L A.]]
+
[[Category: Raag R]]
-
[[Category: Veerapandian, B.]]
+
[[Category: Svensson LA]]
-
[[Category: Cytokine]]
+
[[Category: Veerapandian B]]
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:07:51 2009''
+

Current revision

FUNCTIONAL IMPLICATIONS OF INTERLEUKIN-1BETA BASED ON THE THREE-DIMENSIONAL STRUCTURE

PDB ID 4i1b

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4i1b"
Personal tools