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4iwb

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==Novel Fold of FliC/FliS Fusion Protein==
==Novel Fold of FliC/FliS Fusion Protein==
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<StructureSection load='4iwb' size='340' side='right' caption='[[4iwb]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='4iwb' size='340' side='right'caption='[[4iwb]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4iwb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquae Aquae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IWB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IWB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4iwb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IWB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IWB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ory|1ory]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aq_1998, flaA, fliC, fliS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=224324 AQUAE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iwb OCA], [https://pdbe.org/4iwb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iwb RCSB], [https://www.ebi.ac.uk/pdbsum/4iwb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iwb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iwb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iwb OCA], [http://pdbe.org/4iwb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iwb RCSB], [http://www.ebi.ac.uk/pdbsum/4iwb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iwb ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FLAA_AQUAE FLAA_AQUAE]] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
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[https://www.uniprot.org/uniprot/O67806_AQUAE O67806_AQUAE] [https://www.uniprot.org/uniprot/FLAA_AQUAE FLAA_AQUAE] Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Domain fusion is a useful tool in protein design. Here, the structure of a fusion of the heterodimeric flagella-assembly proteins FliS and FliC is reported. Although the ability of the fusion protein to maintain the structure of the heterodimer may be apparent, threading-based structural predictions do not properly fuse the heterodimer. Additional examples of naturally occurring heterodimers that are homologous to full-length proteins were identified. These examples highlight that the designed protein was engineered by the same tools as used in the natural evolution of proteins and that heterodimeric structures contain a wealth of information, currently unused, that can improve structural predictions.
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Protein design by fusion: implications for protein structure prediction and evolution.,Skorupka K, Han SK, Nam HJ, Kim S, Faham S Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2451-60. doi:, 10.1107/S0907444913022701. Epub 2013 Nov 19. PMID:24311586<ref>PMID:24311586</ref>
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==See Also==
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*[[Flagellin 3D structures|Flagellin 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4iwb" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aquae]]
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[[Category: Aquifex aeolicus]]
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[[Category: Faham, S]]
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[[Category: Large Structures]]
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[[Category: Motor protein]]
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[[Category: Faham S]]
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[[Category: Novel fold]]
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Current revision

Novel Fold of FliC/FliS Fusion Protein

PDB ID 4iwb

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