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4j36
From Proteopedia
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| - | {{STRUCTURE_4j36| PDB=4j36 | SCENE= }} | ||
| - | ===Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)=== | ||
| - | {{ABSTRACT_PUBMED_23575632}} | ||
| - | == | + | ==Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)== |
| - | [[http://www.uniprot.org/uniprot/KMO_YEAST KMO_YEAST | + | <StructureSection load='4j36' size='340' side='right'caption='[[4j36]], [[Resolution|resolution]] 2.13Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4j36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J36 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1HR:(1S,2S)-2-(3,4-DICHLOROBENZOYL)CYCLOPROPANECARBOXYLIC+ACID'>1HR</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j36 OCA], [https://pdbe.org/4j36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j36 RCSB], [https://www.ebi.ac.uk/pdbsum/4j36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j36 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KMO_YEAST KMO_YEAST] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.<ref>PMID:12062417</ref> <ref>PMID:15806102</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Monooxygenase 3D structures|Monooxygenase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | <references | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Saccharomyces cerevisiae | + | [[Category: Large Structures]] |
| - | [[Category: Amaral | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: Giorgini | + | [[Category: Amaral M]] |
| - | [[Category: Heyes | + | [[Category: Giorgini F]] |
| - | [[Category: Lafite | + | [[Category: Heyes DJ]] |
| - | [[Category: Levy | + | [[Category: Lafite P]] |
| - | [[Category: Leys | + | [[Category: Levy C]] |
| - | [[Category: Outeiro | + | [[Category: Leys D]] |
| - | [[Category: Scrutton | + | [[Category: Outeiro TF]] |
| - | + | [[Category: Scrutton NS]] | |
| - | + | ||
Current revision
Cocrystal Structure of kynurenine 3-monooxygenase in complex with UPF 648 inhibitor(KMO-394UPF)
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