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4j5m

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{{STRUCTURE_4j5m| PDB=4j5m | SCENE= }}
 
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===Structure of the Cargo Binding Domain from Human Myosin Vb===
 
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{{ABSTRACT_PUBMED_24097982}}
 
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==Disease==
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==Structure of the Cargo Binding Domain from Human Myosin Vb==
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[[http://www.uniprot.org/uniprot/MYO5B_HUMAN MYO5B_HUMAN]] Microvillous inclusion disease. The disease is caused by mutations affecting the gene represented in this entry.
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<StructureSection load='4j5m' size='340' side='right'caption='[[4j5m]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j5m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J5M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j5m OCA], [https://pdbe.org/4j5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j5m RCSB], [https://www.ebi.ac.uk/pdbsum/4j5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j5m ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MYO5B_HUMAN MYO5B_HUMAN] Microvillous inclusion disease. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/MYO5B_HUMAN MYO5B_HUMAN] May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity).<ref>PMID:17462998</ref> <ref>PMID:19542231</ref> <ref>PMID:21282656</ref>
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==Function==
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==See Also==
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[[http://www.uniprot.org/uniprot/MYO5B_HUMAN MYO5B_HUMAN]] May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity).<ref>PMID:17462998</ref> <ref>PMID:19542231</ref> <ref>PMID:21282656</ref>
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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== References ==
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==About this Structure==
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<references/>
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[[4j5m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J5M OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:024097982</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Assis, L H.P.]]
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[[Category: Large Structures]]
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[[Category: Berridge, G.]]
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[[Category: Assis LHP]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Berridge G]]
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[[Category: Delft, F von.]]
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[[Category: Burgess-Brown N]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Mahajan, P.]]
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[[Category: Mahajan P]]
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[[Category: Murakami, M T.]]
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[[Category: Murakami MT]]
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[[Category: Nascimento, A F.Z.]]
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[[Category: Nascimento AFZ]]
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[[Category: Tonoli, C C.C.]]
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[[Category: Tonoli CCC]]
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[[Category: Trindade, D M.]]
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[[Category: Trindade DM]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar M]]
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[[Category: Human myosin vb]]
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[[Category: Von Delft F]]
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[[Category: Intracellular traffic]]
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[[Category: Organelle]]
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[[Category: Protein transport]]
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[[Category: Vesicle]]
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Current revision

Structure of the Cargo Binding Domain from Human Myosin Vb

PDB ID 4j5m

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