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4j83

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(New page: '''Unreleased structure''' The entry 4j83 is ON HOLD Authors: Horowitz, S., Nimtz, J.S., Trievel, R.C. Description: SET7/9 in complex with TAF10K189A peptide and AdoMet)
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'''Unreleased structure'''
 
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The entry 4j83 is ON HOLD
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==SET7/9 in complex with TAF10K189A peptide and AdoMet==
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<StructureSection load='4j83' size='340' side='right'caption='[[4j83]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4j83]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J83 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j83 OCA], [https://pdbe.org/4j83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j83 RCSB], [https://www.ebi.ac.uk/pdbsum/4j83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j83 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SETD7_HUMAN SETD7_HUMAN] Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.<ref>PMID:12588998</ref> <ref>PMID:15099517</ref> <ref>PMID:16141209</ref> <ref>PMID:17108971</ref> <ref>PMID:12540855</ref> <ref>PMID:15525938</ref>
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Authors: Horowitz, S., Nimtz, J.S., Trievel, R.C.
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: SET7/9 in complex with TAF10K189A peptide and AdoMet
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Horowitz S]]
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[[Category: Nimtz JS]]
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[[Category: Trievel RC]]

Current revision

SET7/9 in complex with TAF10K189A peptide and AdoMet

PDB ID 4j83

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