4jq5

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<StructureSection load='4jq5' size='340' side='right'caption='[[4jq5]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='4jq5' size='340' side='right'caption='[[4jq5]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jq5]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQ5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JQ5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jq5]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JQ5 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jnu|4jnu]], [[4jnv|4jnv]], [[4jo7|4jo7]], [[4jo9|4jo9]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.195&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NUPL1, KIAA0410 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jq5 OCA], [https://pdbe.org/4jq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jq5 RCSB], [https://www.ebi.ac.uk/pdbsum/4jq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jq5 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jq5 OCA], [http://pdbe.org/4jq5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jq5 RCSB], [http://www.ebi.ac.uk/pdbsum/4jq5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jq5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NUPL1_HUMAN NUPL1_HUMAN]] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (By similarity).
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[https://www.uniprot.org/uniprot/NUP58_HUMAN NUP58_HUMAN] Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. We present the reconstitution and interdisciplinary analyses of the ~425-kDa inner ring complex (IRC), which forms the central transport channel and diffusion barrier of the NPC, revealing its interaction network and equimolar stoichiometry. The Nsp1*Nup49*Nup57 channel nucleoporin hetero-trimer (CNT) attaches to the IRC solely through the adaptor nucleoporin Nic96. The CNT*Nic96 structure reveals that Nic96 functions as an assembly sensor that recognizes the three dimensional architecture of the CNT, thereby mediating the incorporation of a defined CNT state into the NPC. We propose that the IRC adopts a relatively rigid scaffold that recruits the CNT to primarily form the diffusion barrier of the NPC, rather than enabling channel dilation.
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Architecture of the fungal nuclear pore inner ring complex.,Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A Science. 2015 Aug 27. pii: aac9176. PMID:26316600<ref>PMID:26316600</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4jq5" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Nucleoporin|Nucleoporin]]
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*[[Nucleoporin 3D structures|Nucleoporin 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bley, C J]]
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[[Category: Bley CJ]]
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[[Category: Hoelz, A]]
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[[Category: Hoelz A]]
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[[Category: Mayo, D J]]
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[[Category: Mayo DJ]]
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[[Category: Stuwe, T]]
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[[Category: Stuwe T]]
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[[Category: Nucleocytoplasmic transport]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of the human Nup49CCS2+3* coiled-coil segment

PDB ID 4jq5

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