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4jqy
From Proteopedia
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| - | {{STRUCTURE_4jqy| PDB=4jqy | SCENE= }} | ||
| - | ===Human procaspase-3, crystal form 1=== | ||
| - | {{ABSTRACT_PUBMED_23650375}} | ||
| - | == | + | ==Human procaspase-3, crystal form 1== |
| - | [[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN | + | <StructureSection load='4jqy' size='340' side='right'caption='[[4jqy]], [[Resolution|resolution]] 2.50Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4jqy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JQY FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.495Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jqy OCA], [https://pdbe.org/4jqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jqy RCSB], [https://www.ebi.ac.uk/pdbsum/4jqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jqy ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref> | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Caspase 3D structures|Caspase 3D structures]] |
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Thomsen ND]] |
| - | [[Category: | + | [[Category: Wells JA]] |
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Current revision
Human procaspase-3, crystal form 1
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