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4kp6
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4kp6 is ON HOLD Authors: Gewald, R., Grunwald, C., Egerland, U. Description: Crystal structure of human phosphodiesterase 4B (PDE4B) in complex wit...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative== | |
| + | <StructureSection load='4kp6' size='340' side='right'caption='[[4kp6]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4kp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KP6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1S1:2-ETHYL-2-{[4-(METHYLAMINO)-6-(1H-1,2,4-TRIAZOL-1-YL)-1,3,5-TRIAZIN-2-YL]AMINO}BUTANENITRILE'>1S1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kp6 OCA], [https://pdbe.org/4kp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kp6 RCSB], [https://www.ebi.ac.uk/pdbsum/4kp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kp6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Egerland U]] | ||
| + | [[Category: Gewald R]] | ||
| + | [[Category: Grunwald C]] | ||
Current revision
Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative
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