4l02

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{{STRUCTURE_4l02| PDB=4l02 | SCENE= }}
 
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===Crystal Structure of SphK1 with inhibitor===
 
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{{ABSTRACT_PUBMED_23845219}}
 
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==Function==
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==Crystal Structure of SphK1 with inhibitor==
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[[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
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<StructureSection load='4l02' size='340' side='right'caption='[[4l02]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4l02]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L02 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1V2:(2R,4S)-1-[2-(4-{[4-(3,4-DICHLOROPHENYL)-1,3-THIAZOL-2-YL]AMINO}PHENYL)ETHYL]-2-(HYDROXYMETHYL)PIPERIDIN-4-OL'>1V2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l02 OCA], [https://pdbe.org/4l02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l02 RCSB], [https://www.ebi.ac.uk/pdbsum/4l02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l02 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref>
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==About this Structure==
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==See Also==
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[[4l02]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L02 OCA].
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*[[Sphingosine kinase|Sphingosine kinase]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:023845219</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Sphinganine kinase]]
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[[Category: Large Structures]]
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[[Category: Min, X.]]
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[[Category: Min X]]
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[[Category: Walker, N.]]
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[[Category: Walker N]]
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[[Category: Wang, Z.]]
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[[Category: Wang Z]]
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[[Category: Lipid kinase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal Structure of SphK1 with inhibitor

PDB ID 4l02

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