4l0r

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{{STRUCTURE_4l0r| PDB=4l0r | SCENE= }}
 
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===Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A.===
 
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==Disease==
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==Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A.==
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[[http://www.uniprot.org/uniprot/CEP57_HUMAN CEP57_HUMAN]] Mosaic variegated aneuploidy syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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<StructureSection load='4l0r' size='340' side='right'caption='[[4l0r]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4l0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L0R FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/CEP57_HUMAN CEP57_HUMAN]] Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.<ref>PMID:22321063</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0r OCA], [https://pdbe.org/4l0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l0r RCSB], [https://www.ebi.ac.uk/pdbsum/4l0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l0r ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[4l0r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0R OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/CEP57_HUMAN CEP57_HUMAN] Mosaic variegated aneuploidy syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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==Reference==
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== Function ==
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<references group="xtra"/><references/>
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[https://www.uniprot.org/uniprot/CEP57_HUMAN CEP57_HUMAN] Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2, but that of FGF1.<ref>PMID:22321063</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Ciccosanti, C.]]
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[[Category: Acton TB]]
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[[Category: Everett, J K.]]
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[[Category: Ciccosanti C]]
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[[Category: Hunt, J F.]]
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[[Category: Everett JK]]
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[[Category: Lew, S.]]
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[[Category: Hunt JF]]
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[[Category: Montelione, G T.]]
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[[Category: Lew S]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Sahdev, S.]]
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[[Category: Sahdev S]]
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[[Category: Seetharaman, J.]]
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[[Category: Seetharaman J]]
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[[Category: Su, M.]]
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[[Category: Su M]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Cell cycle]]
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[[Category: Centrosomal protein]]
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[[Category: Cep57]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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Current revision

Crystal structure of FGF2-interacting protein from Homo sapiens. Northeast Structural Genomics Consortium Target HR9027A.

PDB ID 4l0r

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