4l6h

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{{STRUCTURE_4l6h| PDB=4l6h | SCENE= }}
 
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===Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine===
 
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{{ABSTRACT_PUBMED_24524835}}
 
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==Function==
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==Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine==
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[[http://www.uniprot.org/uniprot/METE_CANAL METE_CANAL]] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]
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<StructureSection load='4l6h' size='340' side='right'caption='[[4l6h]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4l6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L6H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HCS:2-AMINO-4-MERCAPTO-BUTYRIC+ACID'>HCS</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6h OCA], [https://pdbe.org/4l6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l6h RCSB], [https://www.ebi.ac.uk/pdbsum/4l6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l6h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/METE_CANAL METE_CANAL] Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.[HAMAP-Rule:MF_00172]
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==About this Structure==
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==See Also==
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[[4l6h]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6H OCA].
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*[[Methionine synthase 3D structures|Methionine synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:024524835</ref><references group="xtra"/><references/>
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[[Category: Candida albicans SC5314]]
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[[Category: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase]]
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[[Category: Large Structures]]
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[[Category: Robertus, J D.]]
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[[Category: Robertus JD]]
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[[Category: Ubhi, D.]]
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[[Category: Ubhi D]]
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[[Category: Cobalamin-independent]]
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[[Category: Dual tim barrel]]
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[[Category: Fungal]]
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[[Category: Methionine synthase]]
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[[Category: Surface entropy reduction]]
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[[Category: Transferase]]
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Current revision

Crystal structure of the Candida albicans Methionine Synthase in complex with Methotrexate and Homocysteine

PDB ID 4l6h

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