4l9c
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the FP domain of human F-box protein Fbxo7 (native)== | |
| - | + | <StructureSection load='4l9c' size='340' side='right'caption='[[4l9c]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4l9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9c OCA], [https://pdbe.org/4l9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9c RCSB], [https://www.ebi.ac.uk/pdbsum/4l9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.<ref>PMID:15145941</ref> <ref>PMID:16510124</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Du Z]] | ||
| + | [[Category: Huang X]] | ||
| + | [[Category: Shang J]] | ||
| + | [[Category: Wang G]] | ||
| + | [[Category: Yang Y]] | ||
Current revision
Crystal structure of the FP domain of human F-box protein Fbxo7 (native)
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Categories: Homo sapiens | Large Structures | Du Z | Huang X | Shang J | Wang G | Yang Y
