This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4l9c
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{STRUCTURE_4l9c| PDB=4l9c | SCENE= }} | ||
| - | ===Crystal structure of the FP domain of human F-box protein Fbxo7 (native)=== | ||
| - | == | + | ==Crystal structure of the FP domain of human F-box protein Fbxo7 (native)== |
| - | [[http://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN | + | <StructureSection load='4l9c' size='340' side='right'caption='[[4l9c]], [[Resolution|resolution]] 2.10Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4l9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9C FirstGlance]. <br> |
| - | [ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9c OCA], [https://pdbe.org/4l9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9c RCSB], [https://www.ebi.ac.uk/pdbsum/4l9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9c ProSAT]</span></td></tr> |
| - | + | </table> | |
| - | + | == Disease == | |
| - | + | [https://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry. | |
| - | <references | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.<ref>PMID:15145941</ref> <ref>PMID:16510124</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Du Z]] | ||
| + | [[Category: Huang X]] | ||
| + | [[Category: Shang J]] | ||
| + | [[Category: Wang G]] | ||
| + | [[Category: Yang Y]] | ||
Current revision
Crystal structure of the FP domain of human F-box protein Fbxo7 (native)
| |||||||||||
Categories: Homo sapiens | Large Structures | Du Z | Huang X | Shang J | Wang G | Yang Y
