4l9c

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{{STRUCTURE_4l9c| PDB=4l9c | SCENE= }}
 
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===Crystal structure of the FP domain of human F-box protein Fbxo7 (native)===
 
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==Disease==
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==Crystal structure of the FP domain of human F-box protein Fbxo7 (native)==
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[[http://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN]] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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<StructureSection load='4l9c' size='340' side='right'caption='[[4l9c]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4l9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L9C FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN]] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.<ref>PMID:15145941</ref> <ref>PMID:16510124</ref>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l9c OCA], [https://pdbe.org/4l9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l9c RCSB], [https://www.ebi.ac.uk/pdbsum/4l9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l9c ProSAT]</span></td></tr>
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[[4l9c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9C OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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<references group="xtra"/><references/>
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== Function ==
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[[Category: Du,Z.]]
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[https://www.uniprot.org/uniprot/FBX7_HUMAN FBX7_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.<ref>PMID:15145941</ref> <ref>PMID:16510124</ref>
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[[Category: Huang,X.]]
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== References ==
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[[Category: Shang,J.]]
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<references/>
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[[Category: Wang,G.]]
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__TOC__
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[[Category: Yang,Y.]]
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</StructureSection>
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[[Category: Alpha/beta fold]]
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[[Category: Homo sapiens]]
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[[Category: Protein binding]]
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[[Category: Large Structures]]
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[[Category: Du Z]]
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[[Category: Huang X]]
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[[Category: Shang J]]
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[[Category: Wang G]]
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[[Category: Yang Y]]

Current revision

Crystal structure of the FP domain of human F-box protein Fbxo7 (native)

PDB ID 4l9c

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