4m5u

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{{STRUCTURE_4m5u| PDB=4m5u | SCENE= }}
 
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===5-(4-FLUOROPHENYL)-3-HYDROXY-6-[4-(1H-1,2,3,4-TETRAZOL-5-YL)PHENYL]-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 pH1N1 endonuclease===
 
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{{ABSTRACT_PUBMED_24055080}}
 
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==Function==
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==5-(4-FLUOROPHENYL)-3-HYDROXY-6-[4-(1H-1,2,3,4-TETRAZOL-5-YL)PHENYL]-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 pH1N1 endonuclease==
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[[http://www.uniprot.org/uniprot/F0TRT1_9INFA F0TRT1_9INFA]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity).[SAAS:SAAS001009_004_020464]
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<StructureSection load='4m5u' size='340' side='right'caption='[[4m5u]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[4m5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Lima/WRAIR1695P/2009(H1N1)) Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M5U FirstGlance]. <br>
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[[4m5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/lima/wrair1695p/2009(h1n1)) Influenza a virus (a/lima/wrair1695p/2009(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5U OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20F:5-(4-FLUOROPHENYL)-3-HYDROXY-6-[4-(1H-TETRAZOL-5-YL)PHENYL]PYRIDIN-2(1H)-ONE'>20F</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5u OCA], [https://pdbe.org/4m5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m5u RCSB], [https://www.ebi.ac.uk/pdbsum/4m5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5u ProSAT]</span></td></tr>
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<ref group="xtra">PMID:024055080</ref><references group="xtra"/><references/>
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</table>
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[[Category: Arnold, E.]]
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__TOC__
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[[Category: Bauman, J D.]]
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</StructureSection>
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[[Category: Das, K.]]
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[[Category: Large Structures]]
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[[Category: Patel, D.]]
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[[Category: Arnold E]]
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[[Category: Cap-snatching]]
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[[Category: Bauman JD]]
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[[Category: Rna binding protein-inhibitor]]
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[[Category: Das K]]
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[[Category: Rna binding protein-inhibitor complex]]
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[[Category: Patel D]]

Current revision

5-(4-FLUOROPHENYL)-3-HYDROXY-6-[4-(1H-1,2,3,4-TETRAZOL-5-YL)PHENYL]-1,2-DIHYDROPYRIDIN-2-ONE bound to influenza 2009 pH1N1 endonuclease

PDB ID 4m5u

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