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4mbq
From Proteopedia
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| - | == | + | |
| - | <StructureSection load='4mbq' size='340' side='right' caption='[[4mbq]], [[Resolution|resolution]] 2.01Å' scene=''> | + | ==TPR3 of FimV from P. aeruginosa (PAO1)== |
| + | <StructureSection load='4mbq' size='340' side='right'caption='[[4mbq]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4mbq]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBQ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4mbq]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MBQ FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.006Å</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mbq OCA], [https://pdbe.org/4mbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mbq RCSB], [https://www.ebi.ac.uk/pdbsum/4mbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mbq ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FIMV_PSEAE FIMV_PSEAE] Inner membrane hub protein that plays both cAMP-dependent and cAMP-independent roles in twitching motility (PubMed:27297880, PubMed:28583947). Regulates intracellular cyclic AMP (cAMP) levels through the activation of adenylate cyclase CyaB (PubMed:20345659). Plays an essential role in a number of virulence mechanisms including type IV pilus (T4P)-mediated assembly and twitching motility as well as cAMP-dependent virulence gene expression (PubMed:21097635, PubMed:10846211). Mediates also type II secretion (T2S) of lipases and proteases (PubMed:21527471). In addition, mediates the cAMP-independent localization of multiple T4P structural and regulatory components to the cell poles (PubMed:21527471, PubMed:27297880, PubMed:28583947). This role in directing proteins to the cell pole is not restricted to type IV component and involves other proteins such as the diguanylate cyclase DgcP (By similarity).[UniProtKB:A0A0H2ZC68]<ref>PMID:10846211</ref> <ref>PMID:20345659</ref> <ref>PMID:21097635</ref> <ref>PMID:21527471</ref> <ref>PMID:27297880</ref> <ref>PMID:28583947</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Burrows | + | [[Category: Large Structures]] |
| - | [[Category: Daniel-Ivad | + | [[Category: Pseudomonas aeruginosa PAO1]] |
| - | [[Category: Howell | + | [[Category: Burrows LL]] |
| - | [[Category: Junop | + | [[Category: Daniel-Ivad M]] |
| - | [[Category: Nguyen | + | [[Category: Howell PL]] |
| - | [[Category: Robinson | + | [[Category: Junop MS]] |
| - | [[Category: Sugiman-Marangos | + | [[Category: Nguyen Y]] |
| - | [[Category: Wolfram | + | [[Category: Robinson H]] |
| - | [[Category: Zhang | + | [[Category: Sugiman-Marangos SN]] |
| - | + | [[Category: Wolfram F]] | |
| - | + | [[Category: Zhang K]] | |
Current revision
TPR3 of FimV from P. aeruginosa (PAO1)
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