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4mt0

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==Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel==
==Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel==
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<StructureSection load='4mt0' size='340' side='right' caption='[[4mt0]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
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<StructureSection load='4mt0' size='340' side='right'caption='[[4mt0]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mt0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MT0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MT0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.292&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4msy|4msy]], [[4msz|4msz]], [[4mt1|4mt1]], [[4mt3|4mt3]], [[4mt4|4mt4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt0 OCA], [http://pdbe.org/4mt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mt0 RCSB], [http://www.ebi.ac.uk/pdbsum/4mt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mt0 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt0 OCA], [https://pdbe.org/4mt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mt0 RCSB], [https://www.ebi.ac.uk/pdbsum/4mt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mt0 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q51006_NEIGO Q51006_NEIGO]
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Active efflux of antimicrobial agents is one of the most important strategies used by bacteria to defend against antimicrobial factors present in their environment. Mediating many cases of antibiotic resistance are transmembrane efflux pumps, composed of one or more proteins. The Neisseria gonorrhoeae MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here describe the crystal structure of N. gonorrhoeae MtrE, the outer membrane component of the MtrCDE tripartite multidrug efflux system. This trimeric MtrE channel forms a vertical tunnel extending down contiguously from the outer membrane surface to the periplasmic end, indicating that our structure of MtrE depicts an open conformational state of this channel.
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Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel.,Lei HT, Chou TH, Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Do SV, Rajashankar KR, Shafer WM, Yu EW PLoS One. 2014 Jun 5;9(6):e97475. doi: 10.1371/journal.pone.0097475. eCollection , 2014. PMID:24901251<ref>PMID:24901251</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4mt0" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bolla, J R]]
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[[Category: Large Structures]]
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[[Category: Su, C C]]
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[[Category: Neisseria gonorrhoeae]]
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[[Category: Yu, E W]]
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[[Category: Bolla JR]]
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[[Category: Beta barrel]]
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[[Category: Su C-C]]
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[[Category: Membrane protein]]
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[[Category: Yu EW]]
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[[Category: Tranport protein]]
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Current revision

Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

PDB ID 4mt0

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