This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4n9c
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)== | |
| + | <StructureSection load='4n9c' size='340' side='right'caption='[[4n9c]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4n9c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N9C FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.751Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ZM:5-NITRO-1H-BENZIMIDAZOLE'>2ZM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9c OCA], [https://pdbe.org/4n9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n9c RCSB], [https://www.ebi.ac.uk/pdbsum/4n9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Baumeister T]] | ||
| + | [[Category: Bravo B]] | ||
| + | [[Category: Dragovich PS]] | ||
| + | [[Category: Giannetti AM]] | ||
| + | [[Category: Ho Y]] | ||
| + | [[Category: Hua R]] | ||
| + | [[Category: Li G]] | ||
| + | [[Category: Liang X]] | ||
| + | [[Category: O'Brien T]] | ||
| + | [[Category: Oh A]] | ||
| + | [[Category: Skelton NJ]] | ||
| + | [[Category: Wang C]] | ||
| + | [[Category: Wang W]] | ||
| + | [[Category: Wang Y]] | ||
| + | [[Category: Xiao Y]] | ||
| + | [[Category: Yuen P]] | ||
| + | [[Category: Zak M]] | ||
| + | [[Category: Zhao G]] | ||
| + | [[Category: Zhao Q]] | ||
| + | [[Category: Zheng X]] | ||
Current revision
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
| |||||||||||
Categories: Homo sapiens | Large Structures | Baumeister T | Bravo B | Dragovich PS | Giannetti AM | Ho Y | Hua R | Li G | Liang X | O'Brien T | Oh A | Skelton NJ | Wang C | Wang W | Wang Y | Xiao Y | Yuen P | Zak M | Zhao G | Zhao Q | Zheng X
