4ndy

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{{STRUCTURE_4ndy| PDB=4ndy | SCENE= }}
 
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===Human MHF1-MHF2 DNA complex===
 
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{{ABSTRACT_PUBMED_24390579}}
 
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==Function==
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==Human MHF1-MHF2 DNA complex==
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[[http://www.uniprot.org/uniprot/CENPX_HUMAN CENPX_HUMAN]] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:6] [[http://www.uniprot.org/uniprot/CENPS_HUMAN CENPS_HUMAN]] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:8]
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<StructureSection load='4ndy' size='340' side='right'caption='[[4ndy]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ndy]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NDY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6.999&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ndy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ndy OCA], [https://pdbe.org/4ndy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ndy RCSB], [https://www.ebi.ac.uk/pdbsum/4ndy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ndy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CENPS_HUMAN CENPS_HUMAN] DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Required for optimal chromatin association of the FA core complex. Required for efficient damage-induced monoubiquitination and focus formation of FANCD2. Stabilizes FAAD24, FANCM and STRA13/CENPX in the FA core complex. Plays a role in DNA interstrand cross-linking (ICL) repair and in recovery of replication forks stalled by topoisomerase I-DNA cleavage intermediates induced by camptothecin. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation. Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation.<ref>PMID:19620631</ref> <ref>PMID:22814378</ref> [REFERENCE:8]
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==About this Structure==
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==See Also==
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[[4ndy]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NDY OCA].
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:024390579</ref><references group="xtra"/><references/>
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__TOC__
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[[Category: Sachpatzidis, A.]]
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</StructureSection>
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[[Category: Saro, D.]]
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[[Category: Homo sapiens]]
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[[Category: Sung, P.]]
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[[Category: Large Structures]]
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[[Category: Xiong, Y.]]
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[[Category: Synthetic construct]]
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[[Category: Zhao, Q.]]
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[[Category: Sachpatzidis A]]
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[[Category: Centromere construction]]
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[[Category: Saro D]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Sung P]]
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[[Category: Dna repair]]
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[[Category: Xiong Y]]
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[[Category: Fancm]]
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[[Category: Zhao Q]]
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[[Category: Fanconi anemia]]
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[[Category: Genome maintenance]]
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[[Category: Histone fold]]
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[[Category: Nucleus]]
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Current revision

Human MHF1-MHF2 DNA complex

PDB ID 4ndy

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